Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry

Table 2

Selected overall helical parameters of the tRNA^Ser microhelix structure (PDB ID: 3GVN) compared to the LNA-RNA hybrid (PDB ID: 1H0Q) and the LNA helix (PDB ID: 2X2Y). The two LNA molecules correspond to two LNA helices located in the asymmetric unit of the crystal structure.

	Twist (°)	Rise (Å)	Slide (°)	Roll (°)	χ-displacement (Å)	Propeller twist (°)
RNA	32.46	2.64	−1.68	6.61	−4.25	−10.46
tRNA^Ser microhelix
LNA-RNA	29.22	2.65	−2.24	6.07	−5.40	−12.84
hybrid
LNA
(molecule A)	25.97	2.81	−2.49	4.08	−6.60	−6.65
tRNA^Ser microhelix
LNA
(molecule B)	26.13	2.84	−2.47	4.15	−6.47	−7.45
tRNA^Ser microhelix