Artificial Specific Binders Directly Recovered from Chemically Modified Nucleic Acid Libraries

Figure 1

Preparation scheme for chemically modified nucleic acid aptamers that bind to VEGF. High nuclease-resistant 2′-methoxy nucleotides were introduced through Post-SELEX modification process (left), and fully modified 2′-OMe RNA aptamers were directly selected from a library of 2′-OMe transcripts (right).