Artificial Specific Binders Directly Recovered from Chemically Modified Nucleic Acid Libraries

Table 3

Modified DNA aptamers containing C5-substituted thymidine having foreign functionalities, which were directly recovered from chemical libraries.

Target	Chemical structure of modified thymidine	Binding affinity 𝐾𝑑	Polymerase used	References
Thalidomide derivative		1.0 𝜇M for 𝑅-isomer	KOD Dash	[55]
Fibrinogen		6.2 ± 1.4 nM	Taq	[57]
TNFRSF9		5 nM	KOD XL	[70]