VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy

Figure 1

Alternative splicing of VEGF-A pre-mRNA. The pre-mRNA of VEGF-A undergoes alternative splicing leading to pro-angiogenic isoforms notated with the number of amino acids and containing as last exon, the exon 8a stemming from the Proximal Splicing Site (PSS) located at the beginning of exon 8. The more recent subfamily of VEGF isoforms containing five members so far, are anti-angiogenic and contain as last exon, the exon 8b resulting of the splicing at the Distal Splicing Site (DSS) located after the exon 8a.