Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mtext>Pd</mml:mtext></mml:mrow><mml:mn mathvariant="bold">2+</mml:mn></mml:msup></mml:mrow></mml:math> Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside

<table>Preparation of the phosphoramidite building block <b>2</b>. Reagents and conditions: (a) H<sub>2</sub>NNH<sub>2</sub><svg height="5.0124998" id="M3" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 4.5999999 5.0124998" width="4.5999999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,5.0125)">
<g transform="translate(72,-67.99)">
<text transform="matrix(1,0,0,-1,-71.95,68.04)">
<tspan style="font-size: 12.50px; " x="0" y="0">⋅</tspan>
</text>
</g>
</g>
</svg>H<sub>2</sub>O; (b) acetylacetone, THF, TFA; (c) DMTrCl, pyridine; (d) TBDMSCl, imidazole, DMF; (e) 2-cyanoethyl-<i>N</i>, <i>N</i>-diisopropylchlorophosphoramidite, triethylamine, CH<sub>2</sub>Cl<sub>2</sub>.</table>

Journal of Nucleic Acids

sch1

Scheme 1

Scheme 1: Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mtext>Pd</mml:mtext></mml:mrow><mml:mn mathvariant="bold">2+</mml:mn></mml:msup></mml:mrow></mml:math> Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside 

Scheme 1 | Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The Pd2+ Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside 