Research Article

Nucleic-Acid-Binding Chromophores as Efficient Indicators of Aptamer-Target Interactions

Figure 7

Specificity of signaling strategy towards aptamer and cognate target. Chromophores used for the (a) ATP, (b) theophylline, and (c) thrombin aptamers, respectively, were Hoechst 33258, TO, and YOYO. Change of fluorescence is the difference in fluorescence intensities of chromophores (25 nM) with 10 nM aptamers and presence or absence of indicated amounts of target.
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247280.fig.007b
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