Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1
Figure 3
Expression of HECTD1 and RNF8 in the cerebellum and cortex of SCA1 and Alzheimer patients. (a, c) RT-PCR analysis of HECTD1, ring finger protein 8 (RNF8), praja ring finger 2 (PJA2), ubiquitin-conjugating enzyme E2W (UBE2W), CD40, TCBA1, MLL, and GAPDH expression in the cerebellum, involving two independent sets of samples derived from (1) young, (2) old healthy controls, (3) SCA1, and (4) Alzheimer patients. (b, d) RT-PCR analysis of HECTD1, RNF8, PJA2, UBE2W, CD40, TCBA1, MLL, and GAPDH expression in the cortex, involving two independent sets of samples derived from (1) young, (2) old healthy controls, (3) SCA1, and (4) Alzheimer individuals.
