Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1

Table 1

Sequence and the matching sites of miR-E1016 and miR-E1108 within HECTD1 3′UTR.

miRNA	Target gene	Gene position	Start site	3′UTR target sequence	Match sequence	miRNA Sequence
E1016	HECTD1	(Ch14:30667550-30668553) (−)	765	aagagacaguuuucugcauugguu	∣∣∣ ∣∣  ∣   ∣∣∣∣∣∣∣∣	ccgucuuaguaauguaguaaccaa
	HECTD1	(Ch14:30670304-30670441) (−)	32	gacaaaguguuguugccauuggua	∣  ∣∣  ∣․∣   ∣   ․ ․  ∣∣∣∣∣∣∣	ccgucuuaguaauguaguaaccaa
	HECTD1	(Ch14:30673766-30674154) (−)	67	guaaguuauuuuagaacauugguu	∣   ∣∣ ․  ∣∣∣  ∣  ∣∣∣∣∣∣∣∣	ccgucuuaguaauguaguaaccaa
E1108	HECTD1	(Ch14:30639237-30640029) (−)	762	cauaguuagagucaacauuuu	∣∣․ ․  ∣ ∣   ∣∣∣∣∣∣∣∣	cacucgggcagauuuguaaaa
	HECTD1	(Ch14:30645593-30646219) (−)	472	auaacaauauguuaacauuug	∣  ∣ ․  ∣  ∣  ∣∣∣∣∣∣∣	cacucgggcagauuuguaaaa
	HECTD1	(Ch14:30655178-30655341) (−)	64	aagaaaaaggauuaacauuuu	∣∣  ∣ ∣  ∣∣∣∣∣∣∣∣	cacucgggcagauuuguaaaa
	HECTD1	(Ch14:30672189-30672373) (−)	40	gguaaauuuauuuaacauuuu	∣ ∣  ․․  ․∣  ∣∣∣∣∣∣∣∣	cacucgggcagauuuguaaaa
	HECTD1	(Ch14:30687845-30687983) (−)	56	uuuguauauuauaaacauuua	∣  ․  ․  ∣  ∣∣∣∣∣∣∣∣∣	cacucgggcagauuuguaaaa