Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors
Figure 4
Relationship between target affinity and antisense potency. IC50 as a function of values of 2′,4′--based AONs (solid line) and 2′,4′-BNA/LNA-based AONs (dotted line).