Journal of Nucleic Acids

Research Article

Alternative Splicing of a Novel Inducible Exon Diversifies the CASK Guanylate Kinase Domain

Table 1

CASK E24a is associated with peptide coding capacity in mammals.
SpeciesE24 (bp)Intron 24 (bp)E25 (bp)E24a‡ identityE24a encoded peptide
Horse2031015984100%GLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLL
Dolphin203100668498.3%GLEKSSGQGWLEEKSQPWSWSSTSSPWVPHWSSPERRFLL
Cow20380848498.3%GLEKSSGQGWLEAKSQSWSWSSTPCPWVPHWSSPERRFLL
Mouse203725884selfGLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLL
Rat203723984100%GLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLL
Chimp203714384100%GLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLL
Human203697284100%GLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLL
Armadillo203620784100%GLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLL
Lizard203287884——
Chicken203280984——
Takifugu203118084——
Xenopus20364184——
Zebrafish20325284——
E24, intron 24, and E25 lengths (base pairs, bp) for orthologous CASK genes using the exon numbers from mouse Ensembl transcript CASK-001. ‡Nucleotide sequence identities to mouse E24a as determined by ClustalX alignments of orthologous intron regions. Peptide sequences encoded by E24a (differences from mouse are underscored) are shown in far right column. Dashes indicate the absence of E24a or its encoded peptide in non-mammalian species.