Research Article
Allelic Imbalance in TOR1A mRNA Expression in Manifesting and Non-Manifesting Carriers of the GAG-Deletion
Table 3
Expression ratio of WT to ΔGAG TOR1A in brains from MC and NMC.
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WT/WT: homozygous for the normal allele; WT/ΔGAG-TOR1A: carrier heterozygous for the mutant allele; AS-F, ASWT-R, ASΔE-R: allelic specific set of primers (Figure 1); MC: manifesting carriers; NMC: non-manifesting carrier; GP: globus pallidus; SN: substantia nigra; MCp ± S.D.: mean Cp values of triplicates for each reaction; ΔCp: MCp for WT minus MCp for mutant allele primer for each sample; corrected ΔCp: Mean ΔCp of each RNA sample minus ΔCp of heterozygous genomic DNA sample. |