Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus

<table>DM1 locus: schematic drawing of the DM1 locus, indicating relevant sites and regions, including the expanded CTG-repeat with flanking CTCF-binding sites (CTCFbs), the DNAse hypersensitive site enhancer of <i>SIX5</i>, and transcription start sites (TSS) of the genes located at the DM1 locus. Approximate locations of amplicons used for bisulfite sequencing and qPCR after ChIP are indicated. The 45 kb fragment of genomic DNA that was used to generate the DM300 transgenic mouse line used in this study contains all of the features indicated in this scheme.</table>

Journal of Nucleic Acids

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Figure 1

Figure 1: Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus 