Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D<sub>3</sub> Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra

<table>Effect of EX-(9-39) or NAF on recovery of striatal extracellular DA by EX-4 in 6-OHDA-lesioned rats. Both antagonists were coadministered with EX-4 twice daily for seven days, one week after toxin. Bar at 90–120 min indicates infusion of 100 mM K<sup>+</sup>. Results were analyzed using two-way ANOVA (<svg height="11.375" id="M23" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.637497 11.375" width="66.637497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> between treatments and 43.52 overtime) and a post hoc Bonferroni multiple comparisons test. All basal and evoked 6-OHDA and EX-4 + either EX-(9-39) or NAF groups were significantly different (<svg height="11.375" id="M24" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) from shams or 6-OHDA + EX-4 at all time points.</table>

Journal of Neurodegenerative Diseases

fig3

Figure 3

Figure 3: Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D<sub>3</sub> Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra 

Figure 3 | Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra 