Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington’s Disease and Parkinson’s Disease Human Brains

Figure 3

GluA2 expression levels in human postmortem HD and PD hippocampus and striatum. (a) No significant changes in GluA2 expression in HD or PD hippocampal regions. (b) GluA2 specific changes occur in the putamen (Put) of HD and PD tissue. ^∗𝑃<0.05, ^∗∗𝑃<0.005. (c) Representative images are shown for GluA2 in the dentate gyrus, CA3 and CA1 regions of the hippocampus. (d) Representative images of GluA2 immunostaining in the caudate nucleus and putamen of the striatum. Scale bar for (c) and (d) is 25 𝜇m. (e) High power example image of GluA2 immunolabelling, showing the somatic and dendritic localisations.

(a)

(b)

(c)

(d)

(e)