Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington’s Disease and Parkinson’s Disease Human Brains
Figure 4
GluN1 expression levels in human postmortem HD and PD hippocampal and striatal tissues. (a) GluN1 significantly increased in the DG (dentate gyrus) and CA1 region in HD but no changes in GluN1 expression occur in PD hippocampus in any region. . (b) No significant changes in GluN1 expression levels were observed in HD and PD striata in either the caudate nucleus (CN) or the putamen (Put). (c) Representative images are shown for GluN1 in the dentate gyrus and CA3 and CA1 regions of the hippocampus. (d) Representative striatal images of GluN1 immunostaining in the caudate nucleus and putamen. Scale bar 25 m for both (c) and (d). (e) High power example image of GluN1 immunolabelling, showing the somatic and dendritic localisations.
