Review Article
Cancer Therapy Based on Nanomaterials and Nanocarrier Systems
Table 1
Stimuli that can be utilized to control the behavior and properties of micelles.
| Stimuli | Stimuli origin | Examples | References |
| pH | Decreased pH in cancer site caused by hypoxia and massive cell death | Tumoral acidic extracellular pH targeting of pH-responsive micelles encapsulated doxorubicin for cancer therapy | [31] |
| Temperature | Increased temperature in cancerous tissues owing to their high metabolic activities. External applied heating | Self-assembled, thermosensitive micelles for controlled doxorubicin delivery | [32] |
| Magnetic field | Locally applied magnetic field | Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells | [33] |
| Ultrasound | Locally applied ultrasound | Ultrasonic release of doxorubicin from pluronic P105 micelles | [28] |
| Redox potential | Increased concentration of glutathione inside many cancerous cells | Poly(ethylene glycol)-modified thiolated gelatin nanoparticles for glutathione-responsive intracellular DNA delivery | [34] |
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