Nano-Oncology: Clinical Application for Cancer Therapy and Future Perspectives

Table 10

Polymeric micelles in clinical trials.

Polymeric micelle	Block copolymer	Drug	Diameter (nm)	Indication	Clinical phase
NK012	PEG-PGlu(SN-38)	SN-38	20	Breast cancer	II
NK105	PEG-P(aspartate)	Paclitaxel	85	Advanced stomach cancer	II
SP1049C	Pluronic L61 and F127	Doxorubicin	22–27	Adenocarcinoma of esophagus, gastro esophageal junction and stomach	III
NC-6004	PEG-PGlu(cisplatin)	Cisplatin	30	Solid tumors	I/II
				Breast cancer	I
				Pancreatic cancer	V
Genexol-PM	PEG-P(D,L-lactide)	Paclitaxel	20–50	Non-small-cell lung cancer in combination with carboplatin	II
				Pancreatic cancer in combination with gemcitabine	I/II
				Ovarian cancer in combination with carboplatin