Research Article
Development of Quantitative Structure-Property Relationship Models for Self-Emulsifying Drug Delivery System of 2-Aryl Propionic Acid NSAIDs
Table 4
Solubility of drugs in SEDDS.
| NO. | Formula | Km | Oil : Smix | SKeto (mg·mL−1) | SIbu (mg·mL−1) | (mg·mL−1) | SNap (mg·mL−1) | (mg·mL−1) | (mg·mL−1) |
| 1a | 1 | 1 : 2 | 0.5 : 9.5 | 0.961 | 1.756 | 0.848 | 0.332 | 1.909 | 0.989 | 2a | 1 | 1 : 2 | 1 : 9 | 1.207 | 2.075 | 0.948 | 0.350 | 2.002 | 1.014 | 3a | 1 | 1 : 2 | 1.5 : 8.5 | 1.439 | 2.634 | 1.014 | 0.366 | 2.422 | 1.086 | 4a | 1 | 1 : 1 | 0.5 : 9.5 | 1.519 | 2.293 | 1.054 | 0.423 | 2.072 | 1.139 | 5b | 1 | 1 : 1 | 1 : 9 | 1.464 | 2.552 | 1.199 | 0.426 | 2.144 | 1.146 | 6a | 1 | 1 : 1 | 1.5 : 8.5 | 1.864 | 2.958 | 1.315 | 0.420 | 2.431 | 1.321 | 7a | 1 | 2 : 1 | 0.5 : 9.5 | 1.825 | 2.436 | 1.442 | 0.553 | 2.131 | 1.502 | 8a | 1 | 2 : 1 | 1 : 9 | 1.943 | 2.995 | 1.541 | 0.554 | 2.209 | 1.594 | 9b | 1 | 2 : 1 | 1.5 : 8.5 | 1.674 | 3.221 | 1.564 | 0.552 | 2.457 | 1.689 | 10a | 1 | 3 : 1 | 0.5 : 9.5 | 2.033 | 2.678 | 1.535 | 0.592 | 2.177 | 1.633 | 11a | 1 | 3 : 1 | 1 : 9 | 2.354 | 3.06 | 1.598 | 0.594 | 2.387 | 1.605 | 12a | 1 | 3 : 1 | 1.5 : 8.5 | 2.485 | 3.355 | 1.705 | 0.569 | 2.499 | 1.757 | 13b | 1 | 4 : 1 | 0.5 : 9.5 | 2.155 | 2.762 | 1.541 | 0.596 | 2.355 | 1.842 | 14a | 1 | 4 : 1 | 1 : 9 | 2.438 | 3.112 | 1.647 | 0.618 | 2.497 | 1.871 | 15a | 1 | 4 : 1 | 1.5 : 8.5 | 2.220 | 3.520 | 1.714 | 0.582 | 2.510 | 1.799 | 16a | 2 | 1 : 2 | 0.5 : 9.5 | 0.798 | 1.538 | 0.933 | 0.397 | 1.522 | 0.957 | 17a | 2 | 1 : 2 | 1 : 9 | 0.845 | 1.899 | 0.958 | 0.403 | 1.563 | 0.964 | 18a | 2 | 1 : 2 | 1.5 : 8.5 | 0.856 | 2.164 | 1.042 | 0.390 | 1.475 | 0.956 | 19b | 2 | 1 : 1 | 0.5 : 9.5 | 1.057 | 2.074 | 1.045 | 0.450 | 1.904 | 1.475 | 20a | 2 | 1 : 1 | 1 : 9 | 1.295 | 2.444 | 1.228 | 0.466 | 1.928 | 1.498 | 21a | 2 | 1 : 1 | 1.5 : 8.5 | 1.196 | 2.577 | 1.535 | 0.514 | 1.877 | 1.491 | 22a | 2 | 2 : 1 | 0.5 : 9.5 | 1.438 | 2.608 | 1.465 | 0.609 | 2.165 | 1.777 | 23a | 2 | 2 : 1 | 1 : 9 | 1.353 | 2.824 | 1.569 | 0.620 | 2.091 | 1.836 | 24a | 2 | 2 : 1 | 1.5 : 8.5 | 1.430 | 3.099 | 1.666 | 0.631 | 2.186 | 1.88 | 25a | 2 | 3 : 1 | 0.5 : 9.5 | 1.577 | 2.706 | 1.716 | 0.647 | 2.215 | 1.923 | 26a | 2 | 3 : 1 | 1 : 9 | 1.665 | 3.066 | 1.740 | 0.646 | 2.082 | 2.103 | 27b | 2 | 3 : 1 | 1.5 : 8.5 | 1.600 | 3.418 | 1.830 | 0.696 | 2.229 | 2.009 | 28a | 2 | 4 : 1 | 0.5 : 9.5 | 1.637 | 2.770 | 1.749 | 0.703 | 2.310 | 2.165 | 29a | 2 | 4 : 1 | 1 : 9 | 1.705 | 3.176 | 1.791 | 0.694 | 2.268 | 2.171 | 30a | 2 | 4 : 1 | 1.5 : 8.5 | 1.640 | 3.816 | 1.959 | 0.715 | 2.358 | 2.113 | 31a | 3 | 1 : 2 | 0.5 : 9.5 | 0.840 | 1.495 | 0.839 | 0.414 | 1.483 | 1.378 | 32b | 3 | 1 : 2 | 1 : 9 | 1.018 | 2.356 | 1.015 | 0.437 | 1.653 | 1.405 | 33a | 3 | 1 : 2 | 1.5 : 8.5 | 1.027 | 2.432 | 1.030 | 0.399 | 1.771 | 1.407 | 34a | 3 | 1 : 1 | 0.5 : 9.5 | 1.217 | 2.243 | 1.202 | 0.587 | 1.930 | 1.903 | 35a | 3 | 1 : 1 | 1 : 9 | 1.183 | 2.407 | 1.244 | 0.530 | 1.937 | 1.894 | 36b | 3 | 1 : 1 | 1.5 : 8.5 | 1.330 | 2.918 | 1.300 | 0.497 | 2.100 | 1.939 | 37a | 3 | 2 : 1 | 0.5 : 9.5 | 1.537 | 2.573 | 1.393 | 0.637 | 2.331 | 2.307 | 38a | 3 | 2 : 1 | 1 : 9 | 1.739 | 3.148 | 1.638 | 0.627 | 2.396 | 2.404 | 39b | 3 | 2 : 1 | 1.5 : 8.5 | 1.631 | 3.352 | 1.670 | 0.624 | 2.339 | 2.366 | 40a | 3 | 3 : 1 | 0.5 : 9.5 | 1.746 | 3.059 | 1.644 | 0.651 | 2.552 | 2.637 | 41a | 3 | 3 : 1 | 1 : 9 | 1.803 | 3.494 | 1.752 | 0.680 | 2.458 | 2.659 | 42a | 3 | 3 : 1 | 1.5 : 8.5 | 1.755 | 3.674 | 1.826 | 0.705 | 2.344 | 2.46 | 43a | 3 | 4 : 1 | 0.5 : 9.5 | 1.935 | 3.216 | 1.815 | 0.765 | 2.606 | 2.714 | 44a | 3 | 4 : 1 | 1 : 9 | 1.874 | 3.554 | 1.831 | 0.739 | 2.608 | 2.757 | 45a | 3 | 4 : 1 | 1.5 : 8.5 | 2.033 | 3.687 | 2.012 | 0.749 | 2.439 | 2.676 | 46b | 4 | 1 : 2 | 0.5 : 9.5 | 0.944 | 1.545 | 0.794 | 0.342 | 1.585 | 0.818 | 47a | 4 | 1 : 2 | 1 : 9 | 0.961 | 1.969 | 0.950 | 0.359 | 1.426 | 0.729 | 48a | 4 | 1 : 2 | 1.5 : 8.5 | 0.980 | 2.448 | 0.985 | 0.345 | 1.489 | 0.853 | 49a | 4 | 1 : 1 | 0.5 : 9.5 | 1.302 | 2.219 | 1.047 | 0.438 | 1.844 | 1.102 | 50a | 4 | 1 : 1 | 1 : 9 | 1.316 | 2.754 | 1.134 | 0.476 | 1.722 | 1.262 | 51a | 4 | 1 : 1 | 1.5 : 8.5 | 1.451 | 3.137 | 1.310 | 0.441 | 2.136 | 1.103 | 52b | 4 | 2 : 1 | 0.5 : 9.5 | 1.671 | 2.23 | 1.071 | 0.444 | 2.081 | 1.553 | 53a | 4 | 2 : 1 | 1 : 9 | 1.711 | 2.782 | 1.351 | 0.484 | 2.053 | 1.642 | 54a | 4 | 2 : 1 | 1.5 : 8.5 | 1.863 | 3.328 | 1.316 | 0.442 | 2.422 | 1.496 | 55b | 4 | 3 : 1 | 0.5 : 9.5 | 1.962 | 2.483 | 1.095 | 0.455 | 2.133 | 1.725 | 56a | 4 | 3 : 1 | 1 : 9 | 2.006 | 3.172 | 1.356 | 0.489 | 2.447 | 1.663 | 57a | 4 | 3 : 1 | 1.5 : 8.5 | 2.130 | 3.946 | 1.344 | 0.461 | 2.470 | 1.801 | 58a | 4 | 4 : 1 | 0.5 : 9.5 | 2.092 | 2.545 | 1.168 | 0.458 | 2.427 | 1.94 | 59b | 4 | 4 : 1 | 1 : 9 | 2.124 | 3.380 | 1.385 | 0.503 | 2.519 | 1.892 | 60a | 4 | 4 : 1 | 1.5 : 8.5 | 1.999 | 4.062 | 1.431 | 0.491 | 2.639 | 1.945 | 61a | 5 | 1 : 2 | 0.5 : 9.5 | 0.816 | 1.609 | 0.921 | 0.442 | 1.606 | 0.807 | 62b | 5 | 1 : 2 | 1 : 9 | 0.854 | 2.017 | 0.980 | 0.440 | 1.649 | 1.208 | 63a | 5 | 1 : 2 | 1.5 : 8.5 | 0.876 | 2.101 | 1.002 | 0.423 | 1.701 | 1.273 | 64a | 5 | 1 : 1 | 0.5 : 9.5 | 0.985 | 1.945 | 1.344 | 0.525 | 1.945 | 1.577 | 65a | 5 | 1 : 1 | 1 : 9 | 1.227 | 2.211 | 1.343 | 0.561 | 2.001 | 1.646 | 66a | 5 | 1 : 1 | 1.5 : 8.5 | 1.246 | 2.713 | 1.424 | 0.548 | 2.064 | 1.699 | 67a | 5 | 2 : 1 | 0.5 : 9.5 | 1.398 | 2.662 | 1.544 | 0.689 | 2.134 | 2.134 | 68b | 5 | 2 : 1 | 1 : 9 | 1.610 | 2.853 | 1.678 | 0.678 | 2.286 | 2.010 | 69a | 5 | 2 : 1 | 1.5 : 8.5 | 1.617 | 3.307 | 1.819 | 0.655 | 2.419 | 2.199 | 70a | 5 | 3 : 1 | 0.5 : 9.5 | 1.558 | 2.932 | 1.774 | 0.735 | 2.268 | 2.256 | 71a | 5 | 3 : 1 | 1 : 9 | 1.747 | 3.260 | 1.698 | 0.693 | 2.355 | 2.416 | 72b | 5 | 3 : 1 | 1.5 : 8.5 | 1.791 | 3.617 | 1.841 | 0.694 | 2.495 | 2.300 | 73a | 5 | 4 : 1 | 0.5 : 9.5 | 1.617 | 2.985 | 1.820 | 0.766 | 2.337 | 2.454 | 74a | 5 | 4 : 1 | 1 : 9 | 1.921 | 3.393 | 1.953 | 0.760 | 2.374 | 2.505 | 75a | 5 | 4 : 1 | 1.5 : 8.5 | 1.812 | 3.685 | 2.055 | 0.752 | 2.503 | 2.429 | 76a | 6 | 1 : 2 | 0.5 : 9.5 | 0.839 | 1.769 | 0.849 | 0.381 | 1.544 | 1.439 | 77b | 6 | 1 : 2 | 1 : 9 | 0.906 | 2.163 | 0.951 | 0.371 | 1.665 | 1.32 | 78a | 6 | 1 : 2 | 1.5 : 8.5 | 1.066 | 2.414 | 1.135 | 0.402 | 1.712 | 1.392 | 79a | 6 | 1 : 1 | 0.5 : 9.5 | 1.237 | 2.203 | 1.242 | 0.485 | 1.794 | 1.759 | 80a | 6 | 1 : 1 | 1 : 9 | 1.537 | 2.349 | 1.299 | 0.510 | 1.869 | 1.811 | 81a | 6 | 1 : 1 | 1.5 : 8.5 | 1.513 | 2.938 | 1.527 | 0.540 | 1.962 | 1.88 | 82a | 6 | 2 : 1 | 0.5 : 9.5 | 1.581 | 2.455 | 1.437 | 0.636 | 1.912 | 2.331 | 83b | 6 | 2 : 1 | 1 : 9 | 1.711 | 2.686 | 1.559 | 0.631 | 2.069 | 2.258 | 84a | 6 | 2 : 1 | 1.5 : 8.5 | 1.721 | 3.068 | 1.728 | 0.656 | 2.143 | 2.406 | 85b | 6 | 3 : 1 | 0.5 : 9.5 | 1.768 | 2.710 | 1.647 | 0.668 | 2.295 | 2.500 | 86a | 6 | 3 : 1 | 1 : 9 | 1.980 | 3.265 | 1.775 | 0.659 | 2.652 | 2.657 | 87a | 6 | 3 : 1 | 1.5 : 8.5 | 1.949 | 3.709 | 1.924 | 0.686 | 2.595 | 2.421 | 88a | 6 | 4 : 1 | 0.5 : 9.5 | 1.959 | 3.256 | 1.781 | 0.685 | 2.572 | 2.728 | 89a | 6 | 4 : 1 | 1 : 9 | 1.984 | 3.646 | 1.860 | 0.694 | 2.729 | 2.806 | 90a | 6 | 4 : 1 | 1.5 : 8.5 | 2.155 | 3.742 | 2.069 | 0.725 | 2.798 | 2.793 |
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aTraining set.
bInternal validation set.
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