Bacterial Magnetosome: A Novel Biogenetic Magnetic Targeted Drug Carrier with Potential Multifunctions

Figure 7

Schematic diagram of multifunctional BMs. Chemotherapeutic drug (a), protein drug (b), and radioactive isotope (c) could be loaded onto BMs by cross linkers or chelators. Radioactive isotopes could be incorporated in the membrane of BMs during the formation of BMs (d). Antibodies modified with or without radioactive isotopes or chemotherapeutic drugs could be loaded onto BMs by immunoconjugating the genetic engineering expressed Protein A (e) or fusion protein tag (i) or by streptavidin-mediated conjugation with the biotin-streptavidin-biotin (g). DNA drugs could be absorbed onto BMs modified with cationic silanes (f) or linked to BMs with biotin-streptavidin-biotin (h). Specific protein drug could be expressed in BMs membrane by genetic fusion to BMs membrane protein (j).