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Journal of Nanomaterials
Volume 2011 (2011), Article ID 860376, 6 pages
http://dx.doi.org/10.1155/2011/860376
Research Article

Preparation and Characterization of Self-Emulsified Docetaxel

Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Republic of Korea

Received 3 June 2010; Revised 2 August 2010; Accepted 11 August 2010

Academic Editor: Lu Sun

Copyright © 2011 Gyeong Hae Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this paper was to prepare a self-microemulsifying docetaxel (Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The prepared Dtx-loaded self-microemulsifying system (SMES) showed the initial size of the range of 80–100 nm with narrow size distribution and the negative zeta-potential values. Its morphology was a spherical shape by atomic force microscopy. In experiment of stability, Dtx-loaded SMES prepared in DW and BSA condition showed good stability at 3 7 C for 7 days. The viability of the B16F10 cells incubated with Dtx-loaded SMES, Dtx-solution, and Taxol were decreased as a function of incubation time. In conclusion, we confirmed that Dtx-loaded SMES showed an inhibitory effect for proliferation of B16F10 melanoma cells.