5-Fluorouracil Encapsulated Chitosan Nanoparticles for pH-Stimulated Drug Delivery: Evaluation of Controlled Release Kinetics

Table 4

Average particle size of 5-FU encapsulated chitosan nanoparticles.¹

Chitosan nanoparticle	Average particle size (nm)	Polydispersity index (PDI)	Visual identification	Encapsulation efficiency (%)
0.5 mg/mL 5-FU	243.1±17.9	0.091	Opalescent	69.69±0.3
1.0 mg/mL 5-FU	86.9±1.4	0.262	Clear solution	31.23±0.9
5.0 mg/mL 5-FU	69.1±1.0	0.256	Clear solution	29.98±0.8

¹Chitosan : TPP ratio 2 : 1 (v/v) Tween 80 0.5% (v/v); measurements are performed three times.