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Journal of Nanomaterials
Volume 2012 (2012), Article ID 327369, 14 pages
http://dx.doi.org/10.1155/2012/327369
Research Article

Morphological Characterization of Nanofibers: Methods and Application in Practice

1Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Square 2, 162 06 Prague 6, Czech Republic
2Elmarco, Ltd., V horkách 76, 46007 Liberec, Czech Republic
3Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic
4Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague 4, Czech Republic
5Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague 4, Czech Republic

Received 31 May 2012; Accepted 18 September 2012

Academic Editor: Cheng Wang

Copyright © 2012 Jakub Širc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Bhardwaj and S. C. Kundu, “Electrospinning: a fascinating fiber fabrication technique,” Biotechnology Advances, vol. 28, no. 3, pp. 325–347, 2010. View at Publisher · View at Google Scholar
  2. I. Ahmed, A. S. Ponery, E. K. A. Nur et al., “Morphology, cytoskeletal organization, and myosin dynamics of mouse embryonic fibroblasts cultured on nanofibrillar surfaces,” Molecular and Cellular Biochemistry, vol. 301, no. 1-2, pp. 241–249, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. R. V. Shih, C. N. Chen, S. W. Tsai, J. W. Yng, and O. K. Lee, “Growth of mesenchymal stem cells on electrospun type I collagen nanofibers,” Stem Cells, vol. 24, no. 11, pp. 2391–2397, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. E. J. Chong, T. T. Phan, I. J. Lim et al., “Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution,” Acta Biomaterialia, vol. 3, no. 3, pp. 321–330, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Hadjiargyrou and J. B. Chiu, “Enhanced composite electrospun nanofiber scaffolds for use in drug delivery,” Expert Opinion on Drug Delivery, vol. 5, no. 10, pp. 1093–1106, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. G. Wang, L. S. Wan, Z. M. Liu, X. J. Huang, and Z. K. Xu, “Enzyme immobilization on electrospun polymer nanofibers: an overview,” Journal of Molecular Catalysis B, vol. 56, pp. 189–195, 2009. View at Publisher · View at Google Scholar
  7. X. B. Fu and H. H. Li, “Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions,” Cell and Tissue Research, vol. 335, no. 2, pp. 317–321, 2009. View at Publisher · View at Google Scholar
  8. G. Pellegrini, P. Rama, F. Mavilio, and M. de Luca, “Epithelial stem cells in corneal regeneration and epidermal gene therapy,” Journal of Pathology, vol. 217, no. 2, pp. 217–228, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. X. B. Xing, Y. Q. Wang, and B. J. Li, “Nanofiber drawing and nanodevice assembly in poly(trimethylene terephthalate),” Optics Express, vol. 16, no. 14, pp. 10815–10822, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. K. L. Niece, J. D. Hartgerink, J. J. J. M. Donners, and S. I. Stupp, “Self-assembly combining two bioactive peptide-amphiphile molecules into nanofibers by electrostatic attraction,” Journal of the American Chemical Society, vol. 125, no. 24, pp. 7146–7147, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. M. Huang, Y. Z. Zhang, M. Kotaki, and S. Ramakrishna, “A review on polymer nanofibers by electrospinning and their applications in nanocomposites,” Composites Science and Technology, vol. 63, pp. 2223–2253, 2003. View at Publisher · View at Google Scholar
  12. A. Martins and R. L. Reis, “Electrospinning: processing technique for tissue engineering scaffolding,” International Materials Reviews, vol. 53, pp. 257–274, 2008. View at Publisher · View at Google Scholar
  13. C. J. Luo, S. D. Stoyanov, E. Stride, E. Pelan, and M. Edirisinghe, “Electrospinning versus fibre production methods: from specifics to technological convergence,” Chemical Society Reviews, vol. 41, pp. 4708–4735, 2012. View at Publisher · View at Google Scholar
  14. P. R. Kumar, N. Khan, S. Vivekanandhan, N. Satyanarayana, A. K. Mohanty, and M. Misra, “Nanofibers: effective generation by electrospinning and their applications,” Journal of Nanoscience and Nanotechnology, vol. 12, pp. 1–25, 2012. View at Publisher · View at Google Scholar
  15. G. H. Lee, J. C. Song, and K. B. Yoon, “Controlled wall thickness and porosity of polymeric hollow nanofibers by coaxial electrospinning,” Macromolecular Research, vol. 18, pp. 571–576, 2010. View at Publisher · View at Google Scholar
  16. C. Wang, K. W. Yan, Y. D. Lin, and P. C. H. Hsieh, “Biodegradable core/shell fibers by coaxial electrospinning: processing, fiber characterization, and its application in sustained drug release,” Macromolecules, vol. 43, no. 15, pp. 6389–6397, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Kamperman, L. T. J. Korley, B. Yau, K. M. Johansen, Y. L. Joo, and U. Wiesner, “Nanomanufacturing of continuous composite nanofibers with confinement-induced morphologies,” Polymer Chemistry, vol. 1, no. 7, pp. 1001–1004, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. S. L. Chen, H. Q. Hou, P. Hu, J. H. Wendorff, A. Greiner, and S. Agarwal, “Polymeric nanosprings by bicomponent electrospinning,” Macromolecular Materials and Engineering, vol. 294, no. 4, pp. 265–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. L. Chen, H. Q. Hou, P. Hu, J. H. Wendorff, A. Greiner, and S. Agarwal, “Effect of different bicomponent electrospinning techniques on the formation of polymeric nanosprings,” Macromolecular Materials and Engineering, vol. 294, no. 11, pp. 781–786, 2009. View at Publisher · View at Google Scholar
  20. G. F. Taylor, “Electrically driven jets,” Proceedings of the Royal Society of London A, vol. 313, pp. 453–475, 1969. View at Publisher · View at Google Scholar
  21. J. C. Park, “Electric spinning apparatus for mass-production of nano-fiber,” U.S. Patent, 2008.
  22. O. Jirsak, F. Sanetrnik, D. Lukas, L. Kotek, L. Martinova, and J. Chaloupek, “Method of nanofibers production from polymer solution using electrostatic spinning and a device for carrying out the method,” U.S. Patent, WO, 20060290031, 2006.
  23. D. Lukas, A. Sarkar, and P. Pokorny, “Self-organization of jets in electrospinning from free liquid surface: a generalized approach,” Journal of Applied Physics, vol. 103, no. 8, Article ID 084309, 2008. View at Publisher · View at Google Scholar
  24. Y. J. Ryu, H. Y. Kim, K. H. Lee, H. C. Park, and D. R. Lee, “Transport properties of electrospun nylon 6 nonwoven mats,” European Polymer Journal, vol. 39, no. 9, pp. 1883–1889, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. C. P. Barnes, S. A. Sell, E. D. Boland, D. G. Simpson, and G. L. Bowlin, “Nanofiber technology: designing the next generation of tissue engineering scaffolds,” Advanced Drug Delivery Reviews, vol. 59, no. 14, pp. 1413–1433, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Chen, C. Huang, Q. F. Ke, C. L. He, H. S. Wang, and X. M. Mo, “Preparation and characterization of coaxial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications,” Colloids and Surfaces B, vol. 79, no. 2, pp. 315–325, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Srivastava, M. Marquez, and T. Thorsen, “Microfluidic electrospinning of biphasic nanofibers with Janus morphology,” Biomicrofluidics, vol. 3, no. 1, Article ID 012801, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. K. H. Lee, H. Y. Kim, Y. J. Ryu, K. W. Kim, and S. W. Choi, “Mechanical behavior of electrospun fiber mats of poly(vinyl chloride)/polyurethane polyblends,” Journal of Polymer Science B, vol. 41, no. 11, pp. 1256–1262, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Forouharshad, O. Saligheh, R. Arasteh, and R. E. Farsani, “Manufacture and characterization of poly (butylene terephthalate) nanofibers by electrospinning,” Journal of Macromolecular Science B, vol. 49, no. 4, pp. 833–842, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. L. M. Guerrini, M. P. de Oliveira, M. C. Branciforti, T. A. Custodio, and R. E. S. Bretas, “Thermal and structural characterization of nanofibers of poly(vinyl alcohol) produced by electrospinning,” Journal of Applied Polymer Science, vol. 112, pp. 1680–1687, 2009. View at Publisher · View at Google Scholar
  31. Z. Q. Peng, Y. Yoshida, and S. Sukigara, “Morphology and physical properties of a novel ramie-PU blended nonwoven by electrospinning: the effect of cosolvent ratio,” Journal of Polymer Science B, vol. 48, no. 1, pp. 1–14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. J. H. Park, H. W. Lee, D. K. Chae et al., “Electrospinning and characterization of poly(vinyl alcohol)/chitosan oligosaccharide/clay nanocomposite nanofibers in aqueous solutions,” Colloid and Polymer Science, vol. 287, no. 8, pp. 943–950, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Lim, G. R. Yi, J. H. Moon, C. J. Heo, and S. M. Yang, “Superhydrophobic films of electrospun fibers with multiple-scale surface morphology,” Langmuir, vol. 23, no. 15, pp. 7981–7989, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. I. Shabani, V. Haddadi-Asl, E. Seyedjafari, F. Babaeijandaghi, and M. Soleimani, “Improved infiltration of stem cells on electrospun nanofibers,” Biochemical and Biophysical Research Communications, vol. 382, no. 1, pp. 129–133, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Martins, E. D. Pinho, S. Faria et al., “Surface modification of electrospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance,” Small, vol. 5, no. 10, pp. 1195–1206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. K. E. Park, K. Z. Lee, S. J. Lee, and W. H. Park, “Surface characteristics of plasma-treated PLGA nanofibers,” Macromolecular Symposia, vol. 249-250, pp. 103–108, 2007. View at Publisher · View at Google Scholar
  37. S. J. Kim, D. H. Jang, W. H. Park, and B. M. Min, “Fabrication and characterization of 3-dimensional PLGA nanofiber/microfiber composite scaffolds,” Polymer, vol. 51, no. 6, pp. 1320–1327, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. C. B. Huang, S. L. Chen, D. H. Reneker, C. L. Lai, and H. Q. Hou, “High-strength mats from electrospun poly(p-phenylene biphenyltetracarboximide) nanofibers,” Advanced Materials, vol. 18, pp. 668–671, 2006. View at Publisher · View at Google Scholar
  39. S. L. Chen, P. Hu, A. Greiner et al., “Electrospun nanofiber belts made from high performance copolyimide,” Nanotechnology, vol. 19, no. 1, Article ID 015604, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. I. K. Kwon, S. Kidoaki, and T. Matsuda, “Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential,” Biomaterials, vol. 26, no. 18, pp. 3929–3939, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. N. Amiraliyan, M. Nouri, and M. H. Kish, “Electrospinning of silk nanofibers. I. An investigation of nanofiber morphology and process optimization using response surface methodology,” Fibers and Polymers, vol. 10, no. 2, pp. 167–176, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. D. H. Reneker, W. Kataphinan, A. Theron, E. Zussman, and A. L. Yarin, “Nanofiber garlands of polycaprolactone by electrospinning,” Polymer, vol. 43, no. 25, pp. 6785–6794, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. V. Jacobs, R. D. Anandjiwala, and M. Maaza, “The influence of electrospinning parameters on the structural morphology and diameter of electrospun nanofibers,” Journal of Applied Polymer Science, vol. 115, no. 5, pp. 3130–3136, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Amiraliyan, M. Nouri, and M. H. Kish, “Effects of some electrospinning parameters on morphology of Natural silk-based nanofibers,” Journal of Applied Polymer Science, vol. 113, no. 1, pp. 226–234, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. E. Tomba, P. Facco, M. Roso, M. Modesti, F. Bezzo, and M. Barolo, “Artificial vision system for the automatic measurement of interfiber pore characteristics and fiber diameter distribution in nanofiber assemblies,” Industrial and Engineering Chemistry Research, vol. 49, no. 6, pp. 2957–2968, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. P. Facco, E. Tomba, M. Roso, M. Modesti, F. Bezzo, and M. Barolo, “Automatic characterization of nanofiber assemblies by image texture analysis,” Chemometrics and Intelligent Laboratory Systems, vol. 103, no. 1, pp. 66–75, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. H. M. Ji, H. W. Lee, M. R. Karim et al., “Electrospinning and characterization of medium-molecular-weight poly(vinyl alcohol)/high-molecular-weight poly(vinyl alcohol)/ montmorillonite nanofibers,” Colloid and Polymer Science, vol. 287, no. 7, pp. 751–758, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Y. Cheng, J. Chen, F. Chen et al., “High-strength and high-toughness polyimide nanofibers: synthesis and characterization,” Journal of Applied Polymer Science, vol. 116, no. 3, pp. 1581–1586, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. B. M. Min, G. Lee, S. H. Kim, Y. S. Nam, T. S. Lee, and W. H. Park, “Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro,” Biomaterials, vol. 25, no. 7-8, pp. 1289–1297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Q. Cao, K. Mchugh, S. Y. Chew, and J. M. Anderson, “The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction,” Journal of Biomedical Materials Research A, vol. 93, pp. 1151–1159, 2010.
  51. U. Stachewicz and A. H. Barber, “Enhanced wetting behavior at electrospun polyamide nanofiber surfaces,” Langmuir, vol. 27, no. 6, pp. 3024–3029, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. K. Y. Hwang, S. D. Kim, Y. W. Kim, and W. R. Yu, “Mechanical characterization of nanofibers using a nanomanipulator and atomic force microscope cantilever in a scanning electron microscope,” Polymer Testing, vol. 29, no. 3, pp. 375–380, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. H. L. Ritter and L. C. Drake, “Pressure porosimeter and determination of complete macropore-size distributions. Pressure porosimeter and determination of complete macropore-size distributions,” Industrial and Engineering Chemistry Analytical Edition, vol. 17, no. 12, pp. 782–786, 1945. View at Publisher · View at Google Scholar
  54. E. W. Washburn, “Note on a method of determining the distribution of pore sizes in a porous material,” Proceedings of the National Academy of Sciences, vol. 7, pp. 115–116, 1921. View at Publisher · View at Google Scholar
  55. J. L. Lowery, N. Datta, and G. C. Rutledge, “Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(ε-caprolactone) fibrous mats,” Biomater, vol. 31, pp. 491–504, 2010. View at Publisher · View at Google Scholar
  56. J. B. Ko, S. W. Lee, D. E. Kim et al., “Fabrication of SiO2-ZrO2 composite fiber mats via electrospinning,” Journal of Porous Materials, vol. 13, no. 3, pp. 325–330, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. S. Brunauer, P. H. Emmett, and E. J. Teller, “Adsorption of gases in multimolecular layers,” Journal of the American Chemical Society, vol. 60, no. 2, pp. 309–319, 1938. View at Scopus
  58. A. M. Bazargan, S. M. A. Fateminia, M. E. Ganji, and M. A. Bahrevar, “Electrospinning preparation and characterization of cadmium oxide nanofibers,” Chemical Engineering Journal, vol. 155, no. 1-2, pp. 523–527, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. S. Imaizumi, H. Matsumoto, K. Suzuki, M. Minagawa, M. Kimura, and A. Tanioka, “Phenolic resin-based carbon thin fibers prepared by electrospinning: additive effects of poly(vinyl butyral) and electrolytes,” Polymer Journal, vol. 41, no. 12, pp. 1124–1128, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. Z. Y. Zhang, X. H. Li, C. H. Wang, S. W. Fu, Y. C. Liu, and C. L. Shao, “Polyacrylonitrile and carbon nanofibers with controllable nanoporous structures by electrospinning,” Macromolecular Materials and Engineering, vol. 294, pp. 673–678, 2009. View at Publisher · View at Google Scholar
  61. Q. P. Pham, U. Sharma, and A. G. Mikos, “Electrospun poly(ε-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration,” Biomacromolecules, vol. 7, pp. 2796–2805, 2006. View at Publisher · View at Google Scholar
  62. J. D. Andrade, Surface and Interfacial Aspects of Biomedical Polymers, Plenum Press, New York, NY, USA, 1985.
  63. R. N. Wenzel, “Resistance of solid surfaces to wetting by water,” Industrial and Engineering Chemistry, vol. 28, pp. 988–994, 1936.
  64. A. B. D. Cassie and S. Baxter, “Wettability of porous surfaces,” Transactions of the Faraday Society, vol. 40, pp. 546–551, 1944. View at Scopus
  65. M. Taniguchi, J. P. Pieracci, and G. Belfort, “Effect of undulations on surface energy: a quantitative assessment,” Langmuir, vol. 17, no. 14, pp. 4312–4315, 2001. View at Publisher · View at Google Scholar · View at Scopus
  66. M. Taniguchi and G. Belfort, “Correcting for surface roughness: advancing and receding contact angles,” Langmuir, vol. 18, no. 16, pp. 6465–6467, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. H. S. Yoo, T. G. Kim, and T. G. Park, “Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery,” Advanced Drug Delivery Reviews, vol. 61, pp. 1033–1042, 2009. View at Publisher · View at Google Scholar
  68. J. Jia, Y. Y. Duan, J. Yu, and J. W. Lu J, “Preparation and immobilization of soluble eggshell membrane protein on the electrospun nanofibers to enhance cell adhesion and growth,” Journal of Biomedical Materials Research A, vol. 86, pp. 364–373, 2008. View at Publisher · View at Google Scholar