Application of Response Surface Methodology for Optimization of Paracetamol Particles Formation by RESS Method

Figure 1

The experimental set-up for RESS process. (1) CO₂ tank, (2) pump, (3) heat exchanger, (4, 5) equilibrium vessels, (6) constant-temperature water bath, (7) preheating tube, (8) expansion device, (9) precipitation unit, (10) collection sample holder, (11) refrigerated water bath circulator, (12) data acquisition system (TI: temperature indicator; TIC: temperature indicator controller; PI: pressure indicator).