Research Article

Application of Response Surface Methodology for Optimization of Paracetamol Particles Formation by RESS Method

Figure 14

LC-MS analysis of paracetamol. (a) Unprocessed (mass spectrum) and (b) RESS processed (mass spectrum) ( 𝑇 E x t r a c t i o n = 3 5 3  K, 𝑃 E x t r a c t i o n = 1 8  MPa, 𝑇 P r e e x p a n s i o n = 4 0 3  K, 𝑇 P o s t e x p a n s i o n = 3 2 3  K, Spray distance = 50 mm).
340379.fig.0014a
(a)
340379.fig.0014b
(b)