Research Article
Application of Response Surface Methodology for Optimization of Paracetamol Particles Formation by RESS Method
Table 2
Box-Behnken experimental design with the observed response.
| Run | | | | | Extraction temperature (K) | Extraction pressure (MPa) | Preexpansion temperature (K) | Postexpansion temperature (K) | Average particle size (μm) |
| 1 | 0 | 1 | 0 | 1 | 333 | 18 | 383 | 323 | 0.136 | 2 | −1 | 0 | 0 | 1 | 313 | 14 | 383 | 323 | 0.301 | 3 | 1 | −1 | 0 | 0 | 353 | 10 | 383 | 298 | 0.164 | 4 | 0 | 1 | 1 | 0 | 333 | 18 | 403 | 298 | 0.407 | 5 | 0 | −1 | 0 | 1 | 333 | 10 | 383 | 323 | 0.236 | 6 | 0 | 1 | 0 | −1 | 333 | 18 | 383 | 273 | 0.663 | 7 | 0 | 1 | −1 | 0 | 333 | 18 | 363 | 298 | 0.748 | 8 | −1 | 0 | 1 | 0 | 313 | 14 | 403 | 298 | 0.588 | 9 | 0 | −1 | −1 | 0 | 333 | 10 | 363 | 298 | 0.25 | 10 | 0 | −1 | 0 | −1 | 333 | 10 | 383 | 273 | 0.745 | 11 | −1 | 0 | 0 | −1 | 313 | 14 | 383 | 273 | 0.867 | 12 | −1 | −1 | 0 | 0 | 313 | 10 | 383 | 298 | 0.307 | 13 | 0 | 0 | −1 | 1 | 333 | 14 | 363 | 323 | 0.231 | 14 | −1 | 1 | 0 | 0 | 313 | 18 | 383 | 298 | 0.855 | 15 | 1 | 0 | 1 | 0 | 353 | 14 | 403 | 298 | 0.417 | 16 | 0 | 0 | 0 | 0 | 333 | 14 | 383 | 298 | 0.496 | 17 | 0 | −1 | 1 | 0 | 333 | 10 | 403 | 298 | 0.218 | 18 | 1 | 0 | 0 | 1 | 353 | 14 | 383 | 323 | 0.147 | 19 | −1 | 0 | −1 | 0 | 313 | 14 | 363 | 298 | 0.503 | 20 | 1 | 1 | 0 | 0 | 353 | 18 | 383 | 298 | 0.305 | 21 | 0 | 0 | 1 | 1 | 333 | 14 | 403 | 323 | 0.187 | 22 | 1 | 0 | 0 | −1 | 353 | 14 | 383 | 273 | 0.685 | 23 | 1 | 0 | −1 | 0 | 353 | 14 | 363 | 298 | 0.45 | 24 | 0 | 0 | 1 | −1 | 333 | 14 | 403 | 273 | 0.777 | 25 | 0 | 0 | −1 | −1 | 333 | 14 | 363 | 273 | 0.827 |
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