Application of Response Surface Methodology for Optimization of Paracetamol Particles Formation by RESS Method

Table 3

Analysis of variance (ANOVA) for response surface quadratic model.

Source	Sum of squares	Degree of freedom	Mean square	𝐹 value	𝑃 value	Significant
Model	1.297052	14	0.0926	5.0579	0.0070	**
𝑥1	0.130834	1	0.1308	7.1427	0.0234	*
𝑥2	0.118803	1	0.1188	6.4859	0.0290	*
𝑥3	0.014352	1	0.0144	0.7835	0.3968	NOS
𝑥4	0.921856	1	0.9219	50.3273	<0.0001	***
𝑥1𝑥2	0.041412	1	0.0414	2.2608	0.1636	NOS
𝑥1𝑥3	0.003481	1	0.0035	0.1900	0.6721	NOS
𝑥1𝑥4	0.000196	1	0.0002	0.0107	0.9197	NOS
𝑥2𝑥3	0.023870	1	0.0239	1.3032	0.2802	NOS
𝑥2𝑥4	0.000081	1	0.0001	0.0044	0.9483	NOS
𝑥3𝑥4	0.000009	1	0.0000	0.0005	0.9828	NOS
𝑥^21	0.000194	1	0.0002	0.0106	0.9200	NOS
𝑥^22	0.017032	1	0.0170	0.9298	0.3576	NOS
𝑥^23	0.000121	1	0.0001	0.0066	0.9369	NOS
𝑥^24	0.000949	1	0.0009	0.0518	0.8245	NOS
Residual	0.183172	10	0.0183
Cor. total	1.480224	24

*Significant at 𝑃<0.05; **Significant at 𝑃<0.01; ***Significant at 𝑃<0.001; NOS, not significant.