- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Nanomaterials
Volume 2012 (2012), Article ID 358782, 10 pages
Formulation of LDL Targeted Nanostructured Lipid Carriers Loaded with Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and In Vitro Cytotoxicity
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan 73461-8174, Iran
Received 11 October 2012; Accepted 13 November 2012
Academic Editor: Li-Hong Liu
Copyright © 2012 Jaber Emami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. W. G. Alani, Y. Bae, D. A. Rao, and G. S. Kwon, “Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel,” Biomaterials, vol. 31, no. 7, pp. 1765–1772, 2010.
- J. H. Kim, Y. S. Kim, S. Kim et al., “Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel,” Journal of Controlled Release, vol. 111, no. 1-2, pp. 228–234, 2006.
- A. O. Nornoo, D. W. Osborne, and D. S. L. Chow, “Cremophor-free intravenous microemulsions for paclitaxel. I: formulation, cytotoxicity and hemolysis,” International Journal of Pharmaceutics, vol. 349, no. 1-2, pp. 108–116, 2008.
- G. J. Fetterly and R. M. Straubinger, “Pharmacokinetics of paclitaxel-containing liposomes in rats,” AAPS PharmSci, vol. 5, no. 4, pp. 90–100, 2003.
- M. J. Hawkins, P. Soon-Shiong, and N. Desai, “Protein nanoparticles as drug carriers in clinical medicine,” Advanced Drug Delivery Reviews, vol. 60, no. 8, pp. 876–885, 2008.
- F. Danhier, N. Lecouturier, B. Vroman et al., “Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation,” Journal of Controlled Release, vol. 133, no. 1, pp. 11–17, 2009.
- F. Lacoeuille, F. Hindre, F. Moal et al., “In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel,” International Journal of Pharmaceutics, vol. 344, no. 1-2, pp. 143–149, 2007.
- U. S. Sharma, S. V. Balasubbamanian, and R. M. Straubinger, “Pharmaceutical and physical properties of paclitaxel (Taxol) complexes with cyclodextrins,” Journal of Pharmaceutical Sciences, vol. 84, no. 10, pp. 1223–1230, 1995.
- B. Elsadek, R. Graeser, N. Esser et al., “Development of a novel prodrug of paclitaxel that is cleaved by prostate-specific antigen: an in vitro and in vivo evaluation study,” European Journal of Cancer, vol. 46, no. 18, pp. 3434–3444, 2010.
- X. Zhang, J. K. Jackson, and H. M. Burt, “Development of amphiphilic diblock copolymers as micellar carriers of taxol,” International Journal of Pharmaceutics, vol. 132, no. 1-2, pp. 195–206, 1996.
- S. C. Kim, D. W. Kim, Y. H. Shim et al., “In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy,” Journal of Controlled Release, vol. 72, no. 1–3, pp. 191–202, 2001.
- T. Hamaguchi, Y. Matsumura, M. Suzuki et al., “NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel,” British Journal of Cancer, vol. 92, no. 7, pp. 1240–1246, 2005.
- C. Zhang, P. Qineng, and H. Zhang, “Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system,” Colloids and Surfaces B, vol. 39, no. 1-2, pp. 69–75, 2004.
- F. Q. Hu, G. F. Ren, H. Yuan, Y. Z. Du, and S. Zeng, “Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel,” Colloids and Surfaces B, vol. 50, no. 2, pp. 97–103, 2006.
- M. Huo, Y. Zhang, J. Zhou, A. Zou, and J. Li, “Formation, microstructure, biodistribution and absence of toxicity of polymeric micelles formed by N-octyl-N,O-carboxymethyl chitosan,” Carbohydrate Polymers, vol. 83, no. 4, pp. 1959–1969, 2011.
- R. H. Müller, K. Mäder, and S. Gohla, “Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 1, pp. 161–177, 2000.
- R. H. Müller, M. Radtke, and S. A. Wissing, “Nanostructured lipid matrices for improved microencapsulation of drugs,” International Journal of Pharmaceutics, vol. 242, no. 1-2, pp. 121–128, 2002.
- K. V. Pinheiro, V. T. M. Hungria, E. S. Ficker, C. J. Valduga, C. H. Mesquita, and R. C. Maranhão, “Plasma kinetics of a cholesterol-rich microemulsion (LDE) in patients with Hodgkin's and non-Hodgkin's lymphoma and a preliminary study on the toxicity of etoposide associated with LDE,” Cancer Chemotherapy and Pharmacology, vol. 57, no. 5, pp. 624–630, 2006.
- R. C. Maranh, S. R. Graziani, and N. Yamaguchi, “Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients,” Cancer Chemotherapy and Pharmacology, vol. 49, pp. 487–498, 2002.
- C. J. Valduga, D. C. Fernandes, A. C. Lo Prete, C. H. M. Azevedo, D. G. Rodrigues, and R. C. Maranhão, “Use of a cholesterol-rich microemulsion that binds to low-density lipoproteins receptors as vehicle for etoposide,” Journal of Pharmacy and Pharmacology, vol. 55, no. 12, pp. 1615–1622, 2003.
- D. G. Rodrigues, D. A. Maria, D. C. Fernandes et al., “Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies,” Cancer Chemotherapy and Pharmacology, vol. 55, no. 6, pp. 565–576, 2005.
- N. Nishiyama and K. Kataoka, “Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery,” Pharmacology and Therapeutics, vol. 112, no. 3, pp. 630–648, 2006.
- L. Serpe, M. G. Catalano, R. Cavalli et al., “Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 58, no. 3, pp. 673–680, 2004.
- X. G. Zhang, J. Miao, Y. Q. Dai, Y. Z. Du, H. Yuan, and F. Q. Hu, “Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells,” International Journal of Pharmaceutics, vol. 361, no. 1-2, pp. 239–244, 2008.
- M. K. Lee, S. J. Lim, and C. K. Kim, “Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles,” Biomaterials, vol. 28, no. 12, pp. 2137–2146, 2007.
- R. Li, J. S. Eun, and M. K. Lee, “Pharmacokinetics and biodistribution of paclitaxel loaded in pegylated solid lipid nanoparticles after intravenous administration,” Archives of Pharmacal Research, vol. 34, no. 2, pp. 331–337, 2011.
- H. Yuan, J. Miao, Y. Z. Du, J. You, F. Q. Hu, and S. Zeng, “Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells,” International Journal of Pharmaceutics, vol. 348, no. 1-2, pp. 137–145, 2008.
- D. Liu, Z. Liu, L. Wang, C. Zhang, and N. Zhang, “Nanostructured lipid carriers as novel carrier for parenteral delivery of docetaxel,” Colloids and Surfaces B, vol. 85, no. 2, pp. 262–269, 2011.
- F. Q. Hu, Y. Zhang, Y. Z. Du, and H. Yuan, “Nimodipine loaded lipid nanospheres prepared by solvent diffusion method in a drug saturated aqueous system,” International Journal of Pharmaceutics, vol. 348, no. 1-2, pp. 146–152, 2008.
- F. Q. Hu, S. P. Jiang, Y. Z. Du, H. Yuan, Y. Q. Ye, and S. Zeng, “Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system,” Colloids and Surfaces B, vol. 45, no. 3-4, pp. 167–173, 2005.
- R. H. Müller, M. Radtke, and S. A. Wissing, “Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations,” Advanced Drug Delivery Reviews, vol. 54, pp. S131–S155, 2002.
- J. Varshosaz, S. Eskandari, and M. Tabbakhian, “Freeze-drying of nanostructure lipid carriers by different carbohydrate polymers used as cryoprotectants,” Carbohydrate Polymer, vol. 88, pp. 1157–1163, 2012.
- C. Freitas and R. H. Müller, “Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN) dispersions,” International Journal of Pharmaceutics, vol. 168, no. 2, pp. 221–229, 1998.
- S. J. Lim and C. K. Kim, “Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid,” International Journal of Pharmaceutics, vol. 243, no. 1-2, pp. 135–146, 2002.
- V. C. F. Mosqueira, P. Legrand, J. L. Morgat et al., “Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density,” Pharmaceutical Research, vol. 18, no. 10, pp. 1411–1419, 2001.
- E. B. Souto, S. A. Wissing, C. M. Barbosa, and R. H. Müller, “Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery,” International Journal of Pharmaceutics, vol. 278, no. 1, pp. 71–77, 2004.
- A. Saez, M. Guzmán, J. Molpeceres, and M. R. Aberturas, “Freeze-drying of polycaprolactone and poly(D,L-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 3, pp. 379–387, 2000.