Table 1: Definition and trial levels of factors in Taguchi L8 orthogonal array experiment used in production of NLCs loaded with PTX.

Studied variableLevel 1Level 2

Oleic acid content (w/w %)1530
Surfactant typePoloxamer188Tween80
Drug/lipid ratio %510
Surfactant concentration %12
Sonication time (min)24
Homogenization rate (rpm)8001300