Formulation of LDL Targeted Nanostructured Lipid Carriers Loaded with Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and In Vitro Cytotoxicity

Table 2

Formulations of NLCs produced by a Taguchi design in a standard orthogonal array (L8).

Code	Wt% OA	Surfactant type	Drug/lipid; ratio	Surfactant; conc.	Sonication time; (min)	Homogenization rate; (rpm)
O15P1	15	Poloxamer188	5	1	2	800
O30T2	30	Tween80	5	2	2	800
O30P1	30	Poloxamer188	10	1	4	800
O15P2	15	Poloxamer188	5	2	4	1300
O15T1	15	Tween80	10	1	2	1300
O30T1	30	Tween80	5	1	4	1300
O30P2	30	Poloxamer188	10	2	2	1300
O15T2	15	Tween80	10	2	4	800