Table 2: Formulations of NLCs produced by a Taguchi design in a standard orthogonal array (L8).

Code Wt% OA Surfactant type Drug/lipid ratio Surfactant conc. Sonication time (min) Homogenization rate (rpm) O15P1 15 Poloxamer188 5 1 2 800 O30T2 30 Tween80 5 2 2 800 O30P1 30 Poloxamer188 10 1 4 800 O15P2 15 Poloxamer188 5 2 4 1300 O15T1 15 Tween80 10 1 2 1300 O30T1 30 Tween80 5 1 4 1300 O30P2 30 Poloxamer188 10 2 2 1300 O15T2 15 Tween80 10 2 4 800