Formulation of LDL Targeted Nanostructured Lipid Carriers Loaded with Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and In Vitro Cytotoxicity

Table 3

Physical properties of different NLCs.

Code	Particle size; (nm)	Pd index	Zeta potential; (mV)	EE*  %	DL**  %	Drug released; after 72 h
O15P1	158.1 ± 17.1	0.1 ± 0.009	−20.8 ± 0.26	63 ± 13.2	3.3 ± 0.5	43.39 ± 6.8
O30T2	80.68 ± 15.9	0.2 ± 0.01	−9.1 ± 0.12	72 ± 11.6	2.8 ± 0.3	53.9 ± 7.6
O30P1	173.6 ± 19.8	0.3 ± 0.02	−12.7 ± 0.19	60 ± 10.3	2.8 ± 0.5	59.3 ± 5.6
O15P2	132.9 ± 21.3	0.2 ± 0.04	−19.7 ± 0.23	63 ± 9.8	2.3 ± 0.4	52.23 ± 4.3
O15T1	189.4 ± 15.6	0.6 ± 0.02	−9.17 ± 0.15	46 ± 10.2	2.1 ± 0.2	50.5 ± 8.5
O30T1	100.9 ± 12.3	0.3 ± 0.01	−12.9 ± 0.15	62 ± 11.6	3.5 ± 0.2	50.23 ± 6.3
O30P2	137.3 ± 13.4	0.1 ± 0.03	−8.8 ± 0.13	53 ± 8.6	2.9 ± 0.5	70.3 ± 5.4
O15T2	169.8 ± 10.8	0.4 ± 0.04	−10.7 ± 0.09	53 ± 7.3	3.1 ± 0.6	63.78 ± 8.1

*EE: entrapment efficiency. **DL: drug loading.