Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats

Figure 5

Total number of (a) alveolar macrophages (AMs), (b) neutrophils, (c) lymphocytes, and (d) eosinophils recovered by BAL from rats 1, 3, 7, 28, and 91 days after intratracheal instillation with 10 (Si 10), 25 (Si 25), 50 (Si 50), 100 (Si 100), or 500 (Si 500) μg Si NW or dispersion medium control (DM). *significantly greater than all groups within a time point; ^#significantly greater than DM, Si 10, Si 25, and Si 50; ^$significantly greater than DM, Si 10, and Si 25; ^∧significantly greater than DM and Si 10; values are means ± standard error (𝑛=8 DM, 𝑛=4 Si NW; 𝑃<0.05).

(a)

(b)

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(d)