Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats

Figure 8

Collagen content measured by the sircol assay in the tissue of the right lungs after lavage was performed in rats 1, 3, 7, 28, and 91 days after intratracheal instillation with 10 (Si 10), 25 (Si 25), 50 (Si 50), 100 (Si 100), or 500 (Si 500) μg Si NW or dispersion medium control (DM). ⁺significantly greater than DM; (𝑛=8 DM, 𝑛=4 Si NW; 𝑃<0.05).