Elimination of Tumor Cells Using Folate Receptor Targeting by Antibody-Conjugated, Gold-Coated Magnetite Nanoparticles in a Murine Breast Cancer Model
Figure 3
Labeling with targeted Au-coated magnetite, followed by exposure to the OMF, produces damage to cells. (a) Cell remnant or “ghost.” (b)-(c) Secondary and backscattered images, respectively, of a cell with an unusually flat appearance. Arrows in (b) delineate the perimeter of the damaged portion of the cell. Arrows in (c) indicate nanoparticle clusters either associated with the edge of the cell membrane, or possibly left behind as the damaged membrane retracted. (d)-(e) Membranous debris commonly found on specifically labeled samples following exposure to the OMF. (d) Secondary image, (e) backscattered image. Arrows in (e) indicate nanoparticle clusters. Size bars: (a) = 10 μm; (b)-(c) = 2 μm; (d)-(e) = 1 μm.
