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Journal of Nanomaterials
Volume 2012 (2012), Article ID 656914, 8 pages
doi:10.1155/2012/656914
Research Article

Factorial Study of Compressive Mechanical Properties and Primary In Vitro Osteoblast Response of PHBV/PLLA Scaffolds

Naznin Sultana1,2 and Tareef Hayat Khan3

1Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
2Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor, 81310 Johor Bahru, Malaysia
3Department of Architecture, Faculty of Built Enviroment, Universiti Teknologi Malaysia, Johor, 81310 Johor Bahru, Malaysia

Received 11 September 2012; Accepted 30 October 2012

Academic Editor: Xiao-Miao Feng

Copyright © 2012 Naznin Sultana and Tareef Hayat Khan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. X. Ma, “Scaffolds for tissue fabrication,” Materials Today, vol. 7, no. 5, pp. 30–40, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. P. A. Holmes, Developments in Crystalline Polymers, Edited by D. C. Bassett, Elsevier Applied Science, London, UK, 1982.
  3. B. Duan, M. Wang, W. Y. Zhou, W. L. Cheung, Z. Y. Li, and W. W. Lu, “Three-dimensional nanocomposite scaffolds fabricated via selective laser sintering for bone tissue engineering,” Acta Biomaterialia, vol. 6, no. 12, pp. 4495–4505, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. H. W. Tong, M. Wang, Z. Y. Li, and W. W. Lu, “Electrospinning, characterization and in vitro biological evaluation of nanocomposite fibers containing carbonated hydroxyapatite nanoparticles,” Biomedical Materials, vol. 5, no. 5, Article ID 054111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Sultana and M. Wang, “PHBV/PLLA-based composite scaffolds fabricated using an emulsion freezing/freeze-drying technique for bone tissue engineering: surface modification and in vitro biological evaluation,” Biofabrication, vol. 4, Article ID 015003, 2012.
  6. N. Sultana and T. H. Khan, “In Vitro degradation of PHBV scaffolds and nHA/PHBV composite scaffolds containing hydroxyapatite nanoparticles for bone tissue engineering,” Journal of Nanomaterials, vol. 2012, Article ID 190950, 12 pages, 2012. View at Publisher · View at Google Scholar
  7. N. Sultana and M. Wang, “PHBV/PLLA-based composite scaffolds containing nano-sized hydroxyapatite particles for bone tissue engineering,” Journal of Experimental Nanoscience, vol. 3, no. 2, pp. 121–132, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. P. X. Ma, R. Zhang, G. Xiao, and R. Franceschi, “Engineering new bone tissue in vitro on highly porous poly(alpha-hydroxyl acids)/hydroxyapatite composite scaffolds,” Journal of Biomedical Materials Research, vol. 54, pp. 284–293, 2001.
  9. H. Wang, Y. Li, Y. Zuo, J. Li, S. Ma, and L. Cheng, “Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering,” Biomaterials, vol. 28, no. 22, pp. 3338–3348, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Whang and K. E. Healy, “Processing of polymer scaffolds: freeze-drying,” in Methods of Tissue Engineering, A. Atala and R. P. Lanza, Eds., p. 1285, Academic Press, San Diego, Calif, USA, 2002.
  11. N. Sultana and M. Wang, “Fabrication of tissue engineering scaffolds using the emulsion freezing/freeze-drying technique and characteristics of the scaffolds,” in Integrated Biomaterials in Tissue Engineering, pp. 63–89, John Wiley & Sons, 2012.
  12. T. J. Webster, C. Ergun, R. H. Doremus, R. W. Siegel, and R. Bizios, “Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics,” Journal of Biomedical Materials Research, vol. 51, pp. 475–483, 2000.
  13. S. Patil, A. Sandberg, E. Heckert, W. Self, and S. Seal, “Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential,” Biomaterials, vol. 28, no. 31, pp. 4600–4607, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Y. Zhou, M. Wang, W. L. Cheung, B. C. Guo, and D. M. Jia, “Synthesis of carbonated hydroxyapatite nanospheres through nanoemulsion,” Journal of Materials Science: Materials in Medicine, vol. 19, no. 1, pp. 103–110, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. G. E. P. Box, J. S. Hunter, and W. G. Hunter, Statistics for Experimenters: Design, Innovation, and Discovery, Wiley-Interscience, Hoboken, NJ, USA, 2nd ed edition, 2005.
  16. N. Sultana and M. Wang, “Fabrication of HA/PHBV composite scaffolds through the emulsion freezing/freeze-drying process and characterisation of the scaffolds,” Journal of Materials Science: Materials in Medicine, vol. 19, no. 7, pp. 2555–2561, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. M. J. Yaszemski, R. G. Payne, W. C. Hayes, R. S. Langer, T. B. Aufdemorte, and A. G. Mikos, “The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold,” Tissue Engineering, vol. 1, pp. 41–52, 1995. View at Publisher · View at Google Scholar
  18. J. D. Andrade, V. Hlady, and A. P. Wei, “Adsorption of complex proteins at interfaces,” Pure and Applied Chemistry, vol. 64, pp. 1777–1781, 1992. View at Publisher · View at Google Scholar
  19. T. Sun, M. Wang, and W. C. Lee, “Surface characteristics, properties and in vitro biological assessment of a NiTi shape memory alloy after high temperature heat treatment or surface H2O2-oxidation: a comparative study,” Materials Chemistry and Physics, vol. 130, no. 1-2, pp. 45–58, 2011. View at Publisher · View at Google Scholar · View at Scopus