Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs

Table 1

Polymeric micelle formulations in clinical trials [26].

Clinical phase	Diameter	Block copolymer	Drug	Tissue target
I/II	20–50 nm	PEG-P(D,L-lactide)	Paclitaxel	Pancreatic cancer in combination with gemcitabine
				Ovarian cancer in combination with carboplatin
	30 nm	PEG-Pglu(cisplatin)	Cisplatin	Solid tumors
II	20 nm	PEG-PGlu(SN-38)	SN-38	Breast cancer
	20–50 nm	PEG-P(D,L-lactide)	Paclitaxel	Pancreatic cancer
				Non-small-cell lung cancer in combination with carboplatin
	85 nm	PEG-P(aspartate)	Paclitaxel	Advanced stomach cancer
III	22–27 nm	Pluronic L61 and F127	Doxorubicin	Adenocarcinoma of oesophagus, gastroesophageal junction, and stomach
IV	20–50 nm	PEG-P(D,L-lactide)	Paclitaxel	Breast cancer