Self-Assembling Peptide Nanofiber Scaffold Enhanced with RhoA Inhibitor CT04 Improves Axonal Regrowth in the Transected Spinal Cord

Figure 5

Macrophages infiltration, apoptosis, glial scarring, and RhoA expression 1 wk after treatments. (A–D) show that ED1-positive macrophages surround the lesion site; (E–H) show TUNEL-positive apoptosis cells surround the lesion site; (i, j) show the quantification of ED1-positive macrophages (I) and TUNEL-positive apoptosis cells (J). (K–N) show CS56 immunoreactivities surround the lesion site; (O–R) show RhoA-positive cells surround the lesion site. A–H and K–N were taken in the rostral spinal cord 50 μm from the lesion site. O–R were taken in the 200 μm rostral from the lesion site. Scale bar is 50 μm for all images.