Control of In Vivo Transport and Toxicity of Nanoparticles by Tea Melanin
Figure 5
Melanin ameliorates the GNP-induced imbalance of neurotransmitter profiles. Immediately after the passive avoidance test, brain tissues were removed and the levels of monoamines were analyzed by HPLC. The levels of neurotransmitters and their metabolites are shown. (a) Norepinephrine (NE) and 4-hydroxy-3-methoxyphenylglycol (MHPG, metabolite). (b) Dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC, metabolite). (c) 5-Hydroxytyramine (5-HT, serotonin) and 5-hydroxyindoleacetic acid (5-HIAA, metabolite). (d) epinephrine (EPI) and homovanillic acid (HVA, metabolite). Each group of columns contains, in sequence, averaged values from the control group (control), the melanin-treated only group (M), the scopolamine-treated group (scopolamine), the 17 nm GNP-treated group (17 nm), the 37 nm GNP-treated group (37 nm), the melanin pretreatment-plus 17 nm GNP-treated group (M + 17 nm), and the melanin pretreatment-plus 37 nm GNP-treated group (M + 37 nm). *represents and **represents from the student’s t-test.
