759830.fig.007a
(a)
759830.fig.007b
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759830.fig.007c
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759830.fig.007d
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Figure 7: (a) Aging patient: LSPR spectra for each step of the assay. Ag nanoparticles after functionalization with (a-1) anti-ADDL, (a-2) CSF, and (a-3) anti-ADDL. (b) Alzheimer’s disease patient: LSPR spectra for each step of the assay. Ag nanoparticles after functionalization with (b-1) anti-ADDL, (b-2) CSF, and (b-3) anti-ADDL. Reprinted with permission from [15]. Copyright 2005 American Chemical Society. (c) Number of HRP molecules per particle estimated. (d) Poisson distributions generated from simulations of HRP diffusion to a single nanoparticle. Reprinted with permission from [16]. Copyright 2011 American Chemical Society.