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Journal of Nanomaterials
Volume 2012 (2012), Article ID 825060, 7 pages
http://dx.doi.org/10.1155/2012/825060
Research Article

Gold Nanorod-Mediated Photothermal Modulation for Localized Ablation of Cancer Cells

1Department of Biomedical Engineering, Yonsei University, 234 Maeji, Heungup, Gangwondo, Wonju 220-710, Republic of Korea
2Department of Radiology, College of Medicine, Yonsei University, Sinchon, Seodaemun, Seoul 120-752, Republic of Korea
3Department of Chemical and Biomolecular Engineering, Yonsei University, Sinchon, Seodaemun, Seoul 120-749, Republic of Korea
4YUHS-KRIBB Medical Convergence Research Institute, Sinchon, Seodaemun, Seoul 120-752, Republic of Korea
5Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, Seoul 120-752, Republic of Korea
6Severance Biomedical Science Institute (SBSI), Shinchon, Seodaemun, Seoul 120-752, Republic of Korea

Received 15 August 2012; Accepted 20 September 2012

Academic Editor: Haiya Li

Copyright © 2012 Yoochan Hong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.