Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes

Figure 3

HNT-liposome-coated surfaces reduce and weaken neutrophil adhesion. (a) Neutrophils adhered to a smooth microtube coated with ES-PEG L-DXR. Scale bar = 100 μm. (b) Neutrophils adhered to an HNT-coated microtube with ES-PEG L-DXR. Scale bar = 100 μm. Insets show representative cell shapes at higher magnification (approximately 20×20 𝜇m). (c) Number of neutrophils adhered to smooth and HNT-coated microtubes per 100,000 μm². (d) Shape factor analysis of neutrophils adhered to smooth and HNT-coated microtubes. **𝑃<0.001.