Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes
Figure 6
HNT-liposome-coated surfaces successfully deliver doxorubicin to cancer cells from a combined solution of cancer cells and neutrophils. Brightfield images of MCF7 cells captured on a smooth surface (a) and an HNT-liposome-coated surface (b), from a combined solution of cancer cells and neutrophils. Internalization of doxorubicin (red) in MCF7 cells captured on a smooth surface (c) and an HNT-liposome-coated surface (d), from a combined solution of cancer cells and neutrophils. All images were taken after 4-day incubation at 37°C. Scale bar = 100 μm. Number of viable MCF7 (e) and COLO 205 (f) cells after capture on smooth and HNT-liposome-coated surfaces. Control samples represent viable cells captured by ES-PEG EL. *. **.
