Table 1:
Description and trial levels of studied factors in Taguchi's L
8
orthogonal array experiment on preparation of doxorubicin loaded in micelles of folate-targeted DEX/RA.
Studied variables
Levels
I
II
CMC (
g/mL)
>17 (
g/mL)
<17 (
g/mL)
Polymer content (mg/100 mL)
27
20
Dextran Mw (Da)
6000
10000
Stirring time (h)
1
0.5
Temperature (°C)
50
40
Stirring rate (rpm)
400
600
Drug concentration (%)
30
15