Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design

Table 1

Description and trial levels of studied factors in Taguchi's L₈ orthogonal array experiment on preparation of doxorubicin loaded in micelles of folate-targeted DEX/RA.

Studied variables	Levels
	I	II
CMC (𝜇g/mL)	>17 (𝜇g/mL)	<17 (𝜇g/mL)
Polymer content (mg/100 mL)	27	20
Dextran Mw (Da)	6000	10000
Stirring time (h)	1	0.5
Temperature (°C)	50	40
Stirring rate (rpm)	400	600
Drug concentration (%)	30	15