Table 1: Description and trial levels of studied factors in Taguchi's L8 orthogonal array experiment on preparation of doxorubicin loaded in micelles of folate-targeted DEX/RA.

Studied variablesLevels
III

CMC ( g/mL)>17 ( g/mL) <17 ( g/mL)
Polymer content (mg/100 mL)27 20
Dextran Mw (Da)600010000
Stirring time (h)1 0.5
Temperature (°C)5040
Stirring rate (rpm)400 600
Drug concentration (%)3015