Table 2: Composition of different formulations investigated in preparation of doxorubicin loaded in folate-targeted DEX/RA micelles of L8 orthogonal array using Taguchi design.

RunCMC ( g/mL)Polymer content (mg/100 mL)DEX MwStirring time (h)Temperature (°C)Stirring rate (rpm)Drug concentration (%)

F1>1727600015040030
F2<1727100000.55060030
F3>1720100000.54040030
F4>172760000.54060015
F5<1720600014060030
F6<17271000014040015
F7<172060000.55040015
F8>17201000015060015