Functionalization of Mesoporous Silicon Nanoparticles for Targeting and Bioimaging Purposes

Figure 1

A schematic figure of the surface modifications of UnTHCPSi-NPs. L-tyrosine is covalently conjugated to the carboxylic groups on the UnTHCPsi surface (A). The UnTHCPSi-NPs are radiolabelled by incorporating radioactive iodine-125 to tyrosine residue (B). Antibodies are conjugated to radiolabelled UnTHCPSi-NPs (C). Finally the UnTHCPSi-NPs are PEGylated with O-PEG physisorption (D).