Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Cisplatin
Figure 8
Cells were incubated with CDDP-FA-ASA-MNPs (Fe content was 5 μg·mL−1) for 6 h. (a), (c), (e) Iron stain, 200x. (a) HNE-1 cells (FR positive), blue stain particles were observed in cytoplasm. (b) Electron microscope image for HNE-1 cells, pinosomes contained magnetic nanoparticles were observed in cytoplasm, 155000x. (c) CNE-2 cells (FR negative), blue stain particles were not observed in cytoplasm. (d) Electron microscope image for CNE-2 cells, magnetic nanoparticles were not observed in cytoplasm, 115000x. (e) Hep-2 cells (FR positive), blue-stain particles were observed in cytoplasm. (f) Electron microscope image for Hep-2 cells, pinosomes contained magnetic nanoparticles were observed in cytoplasm, as arrow shown, 115000x.
