Journal of Nanomaterials

Review Article

Silver Nanoparticles in Alveolar Bone Surgery Devices

Table 4

Studies about dental implants surfaces containing Ag NPs.


Author, year	Type of study	Device	Description of Ag NPs included	Main results

Zhao et al., 2011 [10]	In vitro	Coatings for titanium implants	Titania nanotubes (TiO₂-NTs) incorporated with Ag NPs.	(i) The NT-Ag structure shows some cytotoxicity, that can be reduced by controlling the release rate.
				(ii) Long-term antibacterial ability. Satisfactory osteoconductivity (osteoblast from rat calvarial bone).

Secinti et al., 2011 [74]	In vivo, animal	Coatings on titanium implants	Ag NPs	(i) Biofilm formation inhibition.
				(ii) Nontoxic, and no harmful side effects detected on the kidney, liver, brain, or cornea.

Ionita et al., 2011 [11]	In vitro	Coatings on titanium implants	Ag NPs-HA/TiAlZr	(i) Inhibition of growth of E. coli bacteria.
				(ii) Antibacterial effect of biomimetic coating with Ag NPs is high and close to value of biomimetic coating with silver and antibiotic (Tobrex).

Liao et al., 2010 [12]	In vitro	Coatings on titanium implants	Ag NPs	(i) Ti-Ag NPs specimens significantly inhibited the growth of both Staphylococcus aureus and Escherichia coli than Ti-polished specimen.

Liao et al., 2010 [58]	In vitro	Antibacterial titanium plate	Ag NPs	(i) Ti-Ag NPs surface: remarkable antibacterial and antiadhesive activities to Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans.
				(ii) No detectable cytotoxicity on cultured human gingival fibroblasts (hFGFs).

Ma et al., 2011 [75]	In vitro	Modified titanium implant surface	TiO₂ nanotubular surface with immobilized compound Ag/FGF-2 (fibroblast growth factor-2)	(i) The TiO₂ nanotubular surface with immobilized compound Ag/FGF-2 has excellent cytocompatibility compared to pure Ti.

Flores et al., 2010 [59]	In vitro	Coatings on titanium implants	Ag NPs spontaneously adsorb on Ti/TiO₂	(i) Good resistance to colonization by Pseudomonas aeruginosa.

Mo et al., 2007 [57]	In vitro	Coatings on titanium plates	Ag-HA/TiO₂	(i) Antibacterial activity against: Porphyromonas gingivalis, Prevotella intermedia, Fusohacterium nucleatum, and Streptococcus mutans.