Nanoscaffolds for Guided Cardiac Repair: The New Therapeutic Challenge of Regenerative Medicine

Table 4

Novel approach based on ultrathin nanofilms.

Authors	Technology	Methods	Cell types	Materials	Possible applications	Reference
Pensabene et al., 2009; Mattoli et al., 2009	Polymer nanosheets bearing magnetic nanoparticles	Spin coating method		(i) PVA; (ii) PLLA; (iii) NPs	Biomedical field as free-standing carriers or as plasters	[95, 96]
Ricotti et al., 2010	Polymer nanosheets bearing cells	Spin coating method	C2C12 mouse myoblast cell line	(i) PVA; (ii) PLA	(i) Regenerative medicine; (ii) Muscle tissue engineering; (iii) Drug delivery	[101]
Fujie et al., 2010	Polymer nanosheets bearing cells	Layer-by-layer assembly method	NIH-3T3 mouse fibroblast cell line	(i) COL; (ii) HA	(i) Regenerative medicine; (ii) Cell biology	[97]
Fujie et al., 2011	Polymer nanosheets bearing cells	Spin coating method	H9c2 embryonic myocardium rat cell line	(i) PVA; (ii) PLLA	Building of specific cell culture environments	[99]

PVA: poly(vinyl alcohol); PLLA: poly(L-lactic acid); NPs: iron oxide nanoparticles; PLA: poly(lactic acid); COL: collagen; HA: hyaluronic acid.