Polymeric Nanosuspensions for Enhanced Dissolution of Water Insoluble Drugs

Table 3

Kinetic release rate constants and correlation coefficients of various kinetic models (first 2 hours).

Drug	Sample label	Zero order		First order		Hixson-Crowell
		𝐾0	𝑅^2	𝐾1	𝑅^2	𝐾2	𝑅^2
NIF	A1	0.0038	0.9500	0.0471	0.9453	0.0068	0.9469
	A2	0.0235	0.9260	0.2001	0.9015	0.0325	0.9099
	A3	0.0195	0.7963	0.0881	0.7847	0.0177	0.7885
	A4	0.0392	0.9858	0.1754	0.9751	0.0353	0.9790
CBZ	A1	0.0045	0.0262	0.0010	0.0263	0.0005	0.0262
	A2	0.0214	0.8082	0.0045	0.8076	0.0025	0.8078
	A3	0.0064	0.7631	0.0014	0.7630	0.0008	0.7630
	A4	0.0171	0.6843	0.0038	0.6836	0.0020	0.6838
IBU	A1	0.5817	0.9195	0.0230	0.9167	0.0220	0.9176
	A2	3.7847	0.9115	0.0230	0.9167	0.1531	0.8975
	A3	5.9004	0.9240	0.1435	0.9065	0.1614	0.9125
	A4	2.0760	0.9978	0.0387	0.9982	0.0475	0.9984