About this Journal Submit a Manuscript Table of Contents
Journal of Nanomaterials
Volume 2013 (2013), Article ID 183871, 6 pages
http://dx.doi.org/10.1155/2013/183871
Research Article

Preparation, Characterization, and Cytotoxicity of Various Chitosan Nanoparticles

1Key Laboratory of Sichuan Province in Medicinal Chemistry, Chengdu University, Chengdu 610106, China
2Department of Pathogenic Biology, Chengdu Medical College, Chengdu 610500, China

Received 27 June 2013; Revised 25 August 2013; Accepted 26 August 2013

Academic Editor: Xinqing Chen

Copyright © 2013 Qian Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. F. Jiao, J. Zhou, J. Zhou, G. LiHua, Y. Y. Xing, and X. Li, “Synthesis and characterization of chitosan-based schiff base compounds with aromatic substituent groups,” Iranian Polymer Journal, vol. 20, no. 2, pp. 123–136, 2011. View at Scopus
  2. A. G. Luque-Alcaraz, J. Lizardi, F. M. Goycoolea, et al., “Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles,” Journal of Nanomaterials, vol. 2012, Article ID 265161, 7 pages, 2012. View at Publisher · View at Google Scholar
  3. H. Katas, N. N. S. N. Dzulkefli, and S. Sahudin, “Synthesis of a new potential conjugated TAT-peptide-chitosan nanoparticles carrier via disulphide linkage,” Journal of Nanomaterials, vol. 2012, Article ID 134607, 7 pages, 2012. View at Publisher · View at Google Scholar
  4. P. R. Chen and Y. J. Chuang, “The development of conductive nanoporous chitosan polymer membrane for selective transport of charged molecules,” Journal of Nanomaterials, vol. 2013, Article ID 980857, 6 pages, 2013. View at Publisher · View at Google Scholar
  5. L. Qi, Z. Xu, X. Jiang, C. Hu, and X. Zou, “Preparation and antibacterial activity of chitosan nanoparticles,” Carbohydrate Research, vol. 339, no. 16, pp. 2693–2700, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Shrestha, S. Zhilong, N. K. Gee, and A. Kishen, “Nanoparticulates for antibiofilm treatment and effect of aging on its antibacterial activity,” Journal of Endodontics, vol. 36, no. 6, pp. 1030–1035, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Shrestha and A. Kishen, “The effect of tissue inhibitors on the antibacterial activity of chitosan nanoparticles and photodynamic therapy,” Journal of Endodontics, vol. 38, no. 9, pp. 1275–1278, 2012.
  8. A. Shrestha, S.-W. Fong, B.-C. Khoo, and A. Kishen, “Delivery of antibacterial nanoparticles into dentinal tubules using high-intensity focused ultrasound,” Journal of Endodontics, vol. 35, no. 7, pp. 1028–1033, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Y. Ing, N. M. Zin, A. Sarwar, and H. Katas, “Antifungal activity of chitosan nanoparticles and correlation with their physical properties,” International Journal of Biomaterials, vol. 2012, Article ID 62398, 9 pages, 2012. View at Publisher · View at Google Scholar
  10. M. G. Guerra-Sánchez, J. Vega-Pérez, M. G. Velázquez-del Valle, and A. N. Hernández-Lauzardo, “Antifungal activity and release of compounds on Rhizopus stolonifer (Ehrenb.:Fr.) Vuill. by effect of chitosan with different molecular weights,” Pesticide Biochemistry and Physiology, vol. 93, no. 1, pp. 18–22, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Zhong, R. Chen, R. Xing et al., “Synthesis and antifungal properties of sulfanilamide derivatives of chitosan,” Carbohydrate Research, vol. 342, no. 16, pp. 2390–2395, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Ziani, I. Fernández-Pan, M. Royo, and J. I. Maté, “Antifungal activity of films and solutions based on chitosan against typical seed fungi,” Food Hydrocolloids, vol. 23, no. 8, pp. 2309–2314, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Qi, Z. Xu, X. Jiang, Y. Li, and M. Wang, “Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles,” Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 5, pp. 1397–1399, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Qi and Z. Xu, “In vivo antitumor activity of chitosan nanoparticles,” Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 16, pp. 4243–4245, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Luo, H. Su, X. Wang, L. Wang, and J. Li, “N-Succinyl-chitosan nanoparticles induced mitochondria-dependent apoptosis in K562,” Molecular and Cellular Probes, vol. 26, no. 4, pp. 164–169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Luo, J. Li, and X. Chen, “Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells,” Biomedicine & Pharmacotherapy, vol. 64, no. 8, pp. 521–526, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Li, J. W. Y. Lam, F. Mahtab, et al., “Biotin-decorated fluorescent silica nanoparticles with aggregation-induced emission characteristics: fabrication, cytotoxicity and biological applications,” Journal of Materials Chemistry B, vol. 1, no. 5, pp. 676–684, 2013.
  18. M. Patel, R. K. Vadlapatla, S. Shah, and A. K. Mitra, “Molecular expression and functional activity of sodium dependent multivitamin transporter in human prostate cancer cells,” International Journal of Pharmaceutics, vol. 436, no. 1-2, pp. 324–331, 2012.
  19. G. Russell-Jones, K. McTavish, J. McEwan, J. Rice, and D. Nowotnik, “Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours,” Journal of Inorganic Biochemistry, vol. 98, no. 10, pp. 1625–1633, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Chen, S. Chen, X. Zhao, L. V. Kuznetsova, S. S. Wong, and I. Ojima, “Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery,” Journal of the American Chemical Society, vol. 130, no. 49, pp. 16778–16785, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Chinol, O. De Cobelli, G. Trifirò et al., “Localization of avidin in superficial bladder cancer: a potentially new approach for radionuclide therapy,” European Urology, vol. 44, no. 5, pp. 556–559, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Hama, Y. Urano, Y. Koyama, P. L. Choyke, and H. Kobayashi, “Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin,” Biochemical and Biophysical Research Communications, vol. 348, no. 3, pp. 807–813, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Hama, Y. Urano, Y. Koyama et al., “A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate,” Cancer Research, vol. 67, no. 6, pp. 2791–2799, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Ogawa, N. Kosaka, M. R. Longmire, Y. Urano, P. L. Choyke, and H. Kobayashi, “Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases,” Molecular Pharmaceutics, vol. 6, no. 2, pp. 386–395, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. S. Celej, G. G. Montich, and G. D. Fidelio, “Conformational flexibility of avidin: the influence of biotin binding,” Biochemical and Biophysical Research Communications, vol. 325, no. 3, pp. 922–927, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. S. F. Rosebrough, “Pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin and biotin,” Nuclear Medicine and Biology, vol. 20, no. 5, pp. 663–668, 1993. View at Scopus
  27. B. Schechter, R. Silberman, R. Arnon, and M. Wilchek, “Tissue distribution of avidin and streptavidin injected to mice. Effect of avidin carbohydrate, streptavidin truncated and exogenous biotin,” European Journal of Biochemistry, vol. 189, no. 2, pp. 327–331, 1990. View at Scopus
  28. Q. Yao, L. Gan, S. Hou, et al., “Development and biodistribution of trans-resveratrol loaded chitosan nanoparticles with free amino groups,” Latin American Journal of Pharmacy, vol. 31, no. 7, pp. 1038–1042, 2012.
  29. Q. Yao, S.-X. Hou, X. Zhang, G. Zhao, X.-J. Gou, and J.-Z. You, “Preparation and characterization of biotinylated chitosan nanoparticles,” Acta Pharmaceutica Sinica, vol. 42, no. 5, pp. 557–561, 2007. View at Scopus